The Entourage Effect is the term used to describe the enhanced effects of cannabinoids, such as CBD, when multiple compounds synergistically work together rather than alone. That synergistic effect is known as the Entourage Effect.

Everyone just knows about CBD or THC, but hemp contains much more than just those two cannabinoids.  

Imagine two basketball teams playing against each other. Team red has only one player doing all the shooting, stealing, defending, and rebounding, while team blue has all five players working together doing different things. Which team would win? Obviously team blue will win.

CBD Oil Entourage Effect showing CBG CBC CBN THC with terpenes synergically working together to enhance the effects

Not All Hemp Extracts Are Equal

Just because two companies manufacture CBD oil does not mean the quality is close in terms of effectiveness and safety. 

CBD oil from one company is not the same CBD oil as another. It’s important to understand that many variables come into play to manufacture CBD extracts. 

The hemp plants’ genetics, the extraction method, and the parameters used, and the purification process are three of the several crucial parts of the manufacturing process. 

The first two parts mentioned can be exceptional. Still, if the purification process cannot retain the essential cannabinoids and lighter compounds such as terpenes and flavonoids, it doesn’t make much of a difference. 

Purchasing from a reputable company with extensive knowledge and experience in hemp extraction is crucial to getting a safe but effective product. 

Entourage Effect: What Research Shows

It started In 1998 when Professors Raphael Mechoulam and Shimon Ben-Shabat found the Endocannabinoid System demonstrated an “entourage effect” when they noticed the plant compounds significantly increased the activity of our receptors.

Terpenes enhance the effects of CBD and all cannabinoids by being able to cross the Blood-Brain Barrier

These receptors, which interact with our Endocannabinoid System, play a crucial role in regulating and balancing many body processes such as immune response, communication between cells, sleep cycles, memory, and more.

In 2001, two highly notable researchers John McPartland and Ethan Russo, published a paper titled “Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts.” 

This research paper further examines the claims of Professors Mechoulam and Ben-Shabat on how cannabinoids act with secondary compounds, such as terpenes and flavonoids.

Their research found supporting evidence that extracts rich in both cannabinoids and terpenes increased pharmacological activities that strengthened and broadened clinical applications and improved the therapeutic index.

To summarise, terpenes enhance the effects of cannabinoids, and having terpenes intact with cannabinoids shows a noticeable difference in effects.

More than Just CBD – Cannabinoids, Terpenes, and Flavonoids

What are “minor cannabinoids”?

Minor cannabinoids are cannabinoids, just like CBD or THC, found in hemp. Since they are found in much smaller amounts, ranging from 0.01mg to 5-7mg per 1,000mg of extract, they’re considered “minor” cannabinoids.

Although found in minor amounts, they still play a crucial role in the synergistic effects of CBD products. You would be surprised at how they always make a difference even at those minor amounts.

Research studies of minor cannabinoids lacks compared to CBD. However, they still show promising results for what we know. Here are three cannabinoids of the 113 scientists have discovered to date: 

What is Cannabigerol (CBG)

CBG is the final form of CBGA, which is sometimes called the “stem cell” cannabinoid. Scientists have researched the potential antimicrobial and digestive benefits of CBG.

What is Cannabinol (CBN)

CBN can be produced by aging THC or converting CBD. Many people who use CBN believe that this cannabinoid has sleep-promoting properties, and CBN has been investigated for its potential neuroprotective benefits.

Cannabichromene (CBC)

CBC is a little-known cannabinoid that has been investigated for its potential analgesic benefits. Scientists have researched the activity of CBC at the nervous system’s TRPV1 receptors, which regulate inflammation and pain.

Other notable cannabinoids are Cannabidiolic Acid (CBDA), Cannabidivarin (CBDV), Cannabicitran (CBT), or Tetrahydrocannabivarin (THCV). 

What are Terpenes?

Terpenes are another group of chemical compounds found in hemp and are an essential group of aromatic compounds that give plants their unique fragrance. They’re present in nearly every plant on earth, and anything you can sense and smell from a plant is due to the terpenes present in the plant. 

Health Benefits of Terpenes and Role with Cannabinoids

Not only do terpenes play a crucial role in the Entourage Effect, but they hold a wide range of health benefits. Medicinal properties like anticancer, antimicrobial, antifungal, antiviral, antihyperglycemic, analgesic, anti-inflammatory, and antiparasitic.

Here are three terpenes and their benefits:

What is Beta-Caryophyllene

Since it interacts with your brain’s CB2 receptors, beta-caryophyllene works like a cannabinoid. It doesn’t get you high, however, and this terpene is believed to have potent anti-inflammatory benefits.

What is Linalool

Found in lavender as well as hemp, linalool appears to have impressive antimicrobial benefits. This terpene also interacts with your nervous system, and it might help with depression and anxiety.

What is Guaiol

Guaiol has a piney flavor and aroma, and this terpene may offer antiparasitic benefits. Like many other terpenes, guaiol also appears to have antioxidant effects.

What are Flavonoids? 

Cannabinoids and terpenes have been showing to take all the spotlight as cannabis and CBD products are being widely used. First, people learn about the other cannabinoids—outside of THC or CBD—then they learn about these fantastic compounds called terpenes. However, there is more that contributes to the entourage effect—flavonoids. 

Flavonoids are a group of phytonutrients found in all sorts of fruits, flowers, vegetables, and of course, cannabis & hemp. The primary function of flavonoids is to serve as cell messengers and is also known for giving the plant pigment. 

Flavonoids make the yellow of sunflower pop out against a sunny blue sky and give blueberries their name. However, studies have shown these compounds possess many health benefits.

Scientists have identified thousands of them throughout nature, and some are known to be only found in cannabis and hemp. The flavonoids found in hemp and marijuana are called cannaflavins

In a study conducted in 2011, they found flavonoids to posses the following properties:

  • Anti-inflammatory
  • Antioxidant
  • Neuroprotective
  • Lowers risk of heart disease

Summary on Entourage Effect: Enhancing the Effects of CBD Oil

Cannabinoids work better with a combination of cannabinoids, terpenes, and flavonoids versus a CBD product with fewer compounds or, even worse, just pure CBD.

Don’t forget the analogy of the two basketball teams. Which team do you think would win? The team with five players working together to shoot, pass, defend, rebound, or the team with just one player doing everything?

Obviously, the team with five players working together would win.

Why Choose Colorado Botanicals

Our team at Colorado Botanicals holds decades of experience in each part of the hemp manufacturing process. From the farms to growing hemp organically, the post-process of farming in drying the plants to the crucial extraction and purification process to retain as many cannabinoids, terpenes, flavonoids, and other important plant oils as possible.

If you’re looking for a product that maximizes the full potential of the Entourage Effect, visit our wide variety of products such as our CBD oils, CBD gummies, CBD creams, CBD softgels, or our CBD face mask.

Manufacturing of CBD extracts is not a fixed process, and not all extracts are equal.

To learn more about our high standards and process from seed to exact, make sure to check out our Quality page and our Quality and Consistency blog post. If you want to dive deeper into what makes the best CBD oil, then check out this blog post.

The goal is to extract the most beneficial compounds: the cannabinoids, terpenes, and flavonoids, with the least heat degradation. All while eliminating unwanted compounds such as the gums, lipids, heavy metals, pesticides, and so on.