What is CBN and What are its Benefits?

With all the new research and interest in CBD and THC, you’d think we understand cannabis top to bottom. In reality, we barely know anything about this unique plant genus.

But CBD and THC are just two of 113 known cannabinoids, yet we barely give the other 111 a second look. Case in point, let’s look at what is CBN. What are the benefits of CBN? What does CBN do? How does CBD and CBN differ from each other? And more.

CBN may only be a minor cannabinoid, but it still plays a significant role. If we’re going to understand cannabis, we need to look at the whole picture.

What is CBN?

Cannabinol (CBN) is a cannabinoid created by the breakdown of THCA in the Cannabis sativa L. plant. According to some research – CBN could offer life-changing medical benefits.

We don’t have a vast library of information on CBN, even though its discovery predates CBD and THC by several decades.

CBN first popped up in scientific literature in 1896, making it the first cannabinoid discovered. This was long before CBD (1940) and THC (1964). It’s surprising how little we know, given CBN predates both world wars. But that doesn’t mean we’re totally in the dark.

To understand CBN, it’s vital to discuss THC – specifically its idle pre-decarbed state, tetrahydrocannabinolic acid (THCA). As THCA gets exposed to light and air, it oxidizes and transforms into cannabinolic acid (CBNA).

Over time, UV rays slowly decarboxylate the CBNA, leaving behind CBN. This is why older cannabis has higher levels of CBN compared to fresher plants.

CBN and Terpenes

Like all cannabinoids, CBN performs better with other plant compounds called terpenes. These oily substances are responsible for the aroma and medical benefits of a specific plant.

When combined with other terpenes and cannabinoids – like CBN – it takes advantage of a synergistic relationship called the “entourage effect.” All the compounds within a plant complement and improve each other’s effects.

How Does CBN Work?

Based on current research, CBN has a low affinity for the CB1 receptors. These are in the central nervous system, so anything that binds to the CB1 group will cause intoxication (i.e., THC).

However, CBN appears to bind well with the CB2 endocannabinoid receptors, mainly located in the peripheral systems.

The weak affinity for CB1 has researchers stumped, with some studies showing CBN triggers mild psychotropic effects and others saying the opposite.

The CB2 endocannabinoid receptors tie to various functions, like pain, immune function, inflammation, and digestion. CBN’s binding behavior with the CB2 group explains its many potential benefits – some of which are under debate.

What Does CBN Feel Like and What are its Effects?

CBN oil is available from a few vendors, but it’s far from popular. However, if you do get your hands on some CBN extract products, keep a close record of any health progress. A great product to try is this CBD and CBN oil by Colorado Botanicals.

Without human testimony, it’s hard to determine what CBN feels like. But based on what we see in animals, you could expect some or all of the following:

Relaxation
Increased appetite
Mild intoxication (debated)

There’s also a lot of information about how CBN is sedating and helps as a sleep aid. But that might not be the case, as we’ll cover shortly.

What are the Benefits of CBN?

Although we have a lot to learn, there’s some promising preliminary work about CBN’s many medicinal benefits.

Pain Relief

Like CBD and THC, CBN may have analgesic benefits. One 2019 study in Archives of Oral Biology injected live rats with CBD and CBN. The researchers found both cannabinoids displayed pain-relieving effects.

Most importantly, the authors wrote that a combination of CBD and CBN produced the best effects.

They admit even combined CBD and CBN aren’t as effective as THC at reducing pain.

Glaucoma

Glaucoma was one of the first conditions to put medical cannabis on the map. We know THC helps with glaucoma symptoms, but so might CBN.

A 2007 study by Kogan and Mechoulam examined THC, CBD, and CBN’s effects against intraocular pressure (IOP) in rabbits with ocular hypertension (OHT). Both THC and CBN helped reduce IOP, while CBD was ineffective.

Ocular hypertension occurs when eye pressure exceeds healthy levels and, according to the study, is a key risk factor for glaucoma. Kogan and Mechoulan point out that perhaps THC and CBN don’t treat glaucoma but rather OHT.

Whether these cannabinoids treat the disease or just the symptom remains unclear. But based on what researchers saw, CBN could be as helpful as THC for those with glaucoma.

Appetite Support

CBN may not cause much – if any – intoxication, but it takes a page out of THC’s book regarding appetite.

As we know, THC often leads to a case of the munchies. Some early research suggests CBN does the same, at least according to 2012 research published in Psychopharmacology.

The experimenters noticed increased food intake in rats receiving CBN. Interestingly, researchers noted the mechanism of action occurred through the CB1 receptors.

Even though CBN doesn’t work well with the CB1 group, it appears (at least in this case) enough to notably improve appetite. If the results in rats translate equally to humans, CBN could be an effective alternative to THC for eating problems.

Anti-Inflammatory

Inflammation is a broad symptom that can affect many areas, including the digestive, immune, and musculoskeletal systems. CBD made big headlines in recent years over its potential anti-inflammatory benefits.

Judging by a 2016 study published in Federation of American Societies for Experimental Biology, CBN may have copied CBD in this regard.

Researchers used rats to test the anti-inflammatory effects of several endocannabinoids and phytocannabinoids. They discovered CBN reduced arthritis inflammation in the rodent subjects.

More research is needed, but it’s possible CBN could work well against inflammation, especially when combined with CBD.

Promotes Brain Health

Just because CBN is – at best – mildly intoxicating doesn’t mean it has no impact on the brain. Many cannabinoids, like CBD, show promising neuroprotective benefits that could help prevent or slow down diseases like Alzheimer’s, Parkinson’s, or M.S.

In a 2005 study published in the National Library of Medicine, experimenters tested CBN’s effects on rats with amyotrophic lateral sclerosis (ALS). They discovered that ALS progression dropped in subjects given CBN.

With time, CBN may become a valuable tool in the fight against neurodegenerative diseases.

Sleep

It’s not hard to find plenty of articles saying CBN could be an effective sleep aid. This isn’t a huge stretch, given CBN’s minor interaction with the CB1 receptors.

Ironically, the most famous alleged benefit may be the only one least supported by science. There hasn’t been any recent research beyond a single 1975 human study from Pharmacology.

Experimenters gave five male volunteers a placebo, CBN, THC, and a combination of both, with one week between each. The subjects reported no sedative effects with placebo or CBN alone.

Naturally, all subjects said they felt “drugged, drunk, dizzy, and drowsy” after using THC. But let’s not abandon that just yet. While CBN alone might not help, it looks handy for sleep when combined with THC.

But interestingly, a combination of THC and CBN created the strongest intoxication.

This explains why older cannabis tends to be more sedating, understandably leading to the belief that CBN is a sleep aid.

However, the study’s small sample size isn’t nearly enough to prove anything. At best, it’s another argument for more research.

What is the Difference between CBN and CBD?

CBD and CBN share some things in common, but their differences are fundamental.

What is CBD?

Cannabidiol (CBD) is a non-intoxicating cannabinoid found in all cannabis chemovars. In the U.S., you can legally purchase it as an industrial hemp supplement or in legal state dispensaries.

CBD’s ability to control severe epilepsy is well-established. But evidence also continues to mount about CBD’s potential to help with things like nausea, pain, inflammation, and even acne.

How Does CBN Differ from CBD?

Based on what we know so far, CBD and CBN overlap a lot regarding potential medical benefits. But they’re far from identical.

The most glaring difference is that CBD gets directly produced by its host plant, while CBN only appears after a long oxidation process.

Another way the two cannabinoids differ is in their interaction with THC. CBD is known to shorten and reduce the effects of THC. CBN, on the other hand, appears to increase THC potency.

Finally, CBD doesn’t bind to either cannabinoid receptor, while CBN binds with both to some degree.

Does CBD Get You High?

No, CBD won’t get you high. It doesn’t bind to the CB1 endocannabinoid receptor like THC or CBN, so CBD can’t cause any kind of intoxication.

Is CBN Legal?

Yes, CBN is legal. It’s not a controlled substance, but CBN could be labeled as an analog of THC. If this happens, it would technically fall into the “illegal” category.

Select vendors may offer CBN oil, but considering how little we know, it’s best not to purchase these products unless we can establish reliable quality control practices.

What are the Potential Side Effects of CBN?

The potential side effects of CBN aren’t clear. They likely exist, but we’ve studied so little that we just don’t have anything on record. You’ll also be hard-pressed to find extensive independent reviews attesting to CBN’s benefits.

This is entirely an educated guess, but if we base this question on CBD’s side effects, then it’s likely CBN might share a few in common. Some hypothetical examples could be:

Drowsiness
Diarrhea
Headache
Appetite changes

Without more research and attention, we’ll never know if CBN has side effects.

How Can I Use CBN?

You can use CBN in oil or another extract form, if available. At the moment, CBN oil seems to be the only option, but it’s hard to find from a reputable seller. Capsules and other extracts might come later if CBN takes off like CBD.

One problem is that CBN only forms as cannabis ages. Consequently, some people worry that the plant might be “expired.” Cannabis expiration dates are still a mystery, but the association with old weed does raise a few eyebrows – even if it might not be warranted.

If you want a fantastic natural source of CBN, get it through THC-free broad-spectrum CBD oils. Colorado Botanicals carries an unbeatable line of cannabinoid-rich tinctures, with plenty of CBD, CBN, and other critical compounds.

Colorado Botanicals stands out because their proprietary extraction process naturally retains way more cannabinoids and terpenes.

Don’t take a gamble with some rare and untested CBN extracts. You can get it along with a complete list of other cannabinoids – often for much cheaper.

What is CBN Oil?

CBN oil is a cannabis extract rich in cannabinol – a phytocannabinoid found in cannabis. The CBN is extracted and then suspended in a carrier, like MCT, coconut, or olive oil.

November 13, 2024

What is THCV? The Weight Loss and Focus Cannabinoid

The world of cannabinoids continues to evolve as we learn more and more about the incredible hemp plant. One of the more recent cannabinoids to come to the fore is THCV, a close cousin to THC with a unique twist. Learn what THCV is in this article, then find out the best way to buy this rare and enticing cannabinoid, either online or in a store. What Is THCV? Tetrahydrocannabivarin (THCV) is a naturally occurring variant of delta-9 tetrahydrocannabinol, the cannabinoid most commonly known as “THC.” While highly similar to THC, THCV nonetheless possesses a unique chemical structure, lending it special effects in the human body. Scientists have researched THCV primarily for its potential benefits in regards to weight loss and cognitive health, but much remains to be learned about this naturally beneficial cannabinoid. What Is the Difference Between THCV and THC? Chemically, there is only a slight difference between THCV and the “normal” form of THC. The THCV molecule has an additional “tail” that is not present in THC. Researchers suspect that the interaction between this “tail” and the human nervous system explains why THCV has different effects from THC. In terms of effects, consider THCV to be a more energizing and less intoxicating form of THC. It doesn’t stimulate your CB1 receptors as strongly, the neuroreceptors responsible for THC’s intoxicating effects. But, it appears to have other unique benefits that even go so far as to impact digestion. Is THCV Legal? Yes, since THCV has a different chemical structure from THC, it is not considered a controlled substance in the United States. Instead, THCV products are generally classified as “industrial hemp,” the same category as CBD products. Certain states or local governments may have enacted measures that curtail the sale of THCV. These edicts only apply to transactions that take place within the borders of those jurisdictions, however — not to transactions that take place online. What Are the Benefits of THCV? There remains a lot to be learned about THCV. What we’ve found out about the benefits of this cannabinoid so far, however, is quite impressive to consider: Weight Loss A variety of factors affect obesity — diet, lipid and glucose metabolism, and the presence of other conditions like diabetes. In 2016, a parallel group pilot study sought to determine the effects of THCV on glycemic and lipid parameters in diabetic patients. In the end, the authors accumulated sufficient evidence to conclude that “THCV could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.” In other words, it’s worth continuing to research THCV for weight loss. Insulin sensitivity is another issue that can hinder weight loss in obese and overweight individuals. A 2013 study published in Nutrition & Diabetes found that THCV “ameliorates insulin sensitivity” — at least in mouse models. Whether this therapeutic metabolic effect will be replicated in terms of restoring insulin sensitivity in human beings remains to be seen. Focus There’s evidence that THCV may have overall neuroprotective effects, lending credence to the common claim among THCV users that it helps them focus or improves their mental state. Compared to THC, it certainly seems that users of THCV are more likely to indicate that the cannabinoid improves their psychological condition overall. Part of the driving force behind this common report is the fact that THCV is less intoxicating than THC. As a result, it also incites the unwanted side effects of cannabinoids in the THC family less strongly — users often find that THCV causes less anxiety and paranoia than THC. Some have even found that THCV helps reduce their anxiety. Pain All cannabinoids in the THC family appear to have at least some impact on pain, not the least THCV. A considerable number of studies have now noted THCV as being potentially useful for pain, which should come as no surprise. What might be worthy of pause, however, is THCV’s potential unique utility against pain compared to THC due to its reduced psychoactivity. It has yet to be proven that THCV is any better at reducing pain than THC. What’s clear to anyone who has used the cannabinoid, however, is that THCV does not get you as high, potentially spelling relief for those who want to capture the analgesic powers of Cannabis sativa without becoming unduly intoxicated. Neurological Health Many cannabinoids have been noted as being potentially useful in the treatment of neurological conditions like epilepsy — just not often cannabinoids in the THC family. In addition to epilepsy, however, THCV may even be useful for many other facets of neurological health. Again, one of the primary benefits of THCV over alternatives for the treatment of central nervous system diseases is its reduced intoxicating potential. What Are THCV Effects Like? People who use the cannabinoid generally describe the effects of THCV as being roughly the same as those offered by THC while definitely being toned down a notch. Those who have more experience with cannabis might even note the slightly different overall effect profile that THCV has to offer. Where the level of stimulation offered by a THC strain varies depending on its genetics, THCV strains are almost always energizing — at least to some degree. In this sense, even a strongly indica-leaning THCV hemp strain will still have sativa-like effects. Of course, effects vary between individuals. Some users may note THCV’s reported effects on appetite and metabolism, for instance, while others might not. What’s almost universal among THCV users, however, is the report that THC does, indeed, get you high — even if it isn’t as intoxicating as THC’s conventional form. What Is THCV Used For? People generally use THCV as a happy medium between THC and CBD. Overall, CBD is seen as having impressively pain-relieving effects, but it has hardly any mental effects to speak of. With THC, on the other hand, any medicinal benefits the cannabinoid may have are often drowned out by the cannabinoid’s considerable psychoactivity. THCV meets somewhere in the middle as both less intoxicating than THC but more mentally stimulating than CBD. In fact, CBD can often put people to sleep — something that’s far less likely to happen when you use THCV. How to Use THCV The best method for using THCV depends on the type of THCV product you’re using: THCV Oil When giving THCV oil a try, the first step is to determine how much THCV is in a dose. This cannabinoid is less intoxicating than THC, but you should still dose cautiously. Then, simply use the provided dropper to place the desired dose of THCV oil under your tongue. Hold for 30-60 seconds for maximum absorption, then swallow. THCV Gummies The dosage of THCV gummies is usually clearly posted on the package. Determine the dose of THCV you want to consume, then chew up the appropriate number of gummies to achieve it. Chew slowly and thoroughly to maximize absorption through your mouth’s thin mucosal membranes. THCV Vape Pen Given their fast onset and intense effects, THCV vapes are best enjoyed sparingly until you get the hang of it. Try taking one small puff, holding it for 5-10 seconds, then exhaling fully. Take another (potentially larger) puff after around 15-30 minutes have passed. Then, simply continue vaping throughout the day as desired. THCV Capsules The beauty of THCV capsules is you just swallow one or two capsules for a full dose of THCV. Determine how much THCV each capsule contains, and then swallow the right number to achieve your desired dose. Take more THCV capsules every 3-6 hours or as needed. THCV Side Effects In some cases, THCV can have side effects similar to those often noted in association with THC — paranoia, anxiety, dry mouth, and so on. However, THCV isn’t known to have any specific side effects above and beyond those of THC. All cannabinoids in this family can also interact with medications, so consult with your doctor before taking THCV if you are currently using any prescription drugs. Is THCV Psychoactive? Yes, it is only fair to categorize THCV as psychoactive even though it only has a fraction of the intoxicating power of THC. If you use enough THCV, you will get high — the same can’t be said for CBD, CBG, and other strictly non-intoxicating cannabinoids. Does THCV get you high? Well, it certainly doesn’t lack intoxicating effects. Those expecting THCV to offer the same psychoactivity as THC, however, will likely be disappointed: THCV is called “diet weed” for a reason. THCV vs. Delta-9 THC Compared to delta-9 THC (the “original” form of THC), THCV is certainly less psychoactive. It could be better for inflammatory pain, plasma glucose concentration, and multiple sclerosis — all while potentially triggering beneficial neural effects. Its reduced psychoactive effects make THCV more desirable for everything aside from recreational purposes — the epitome of “medical cannabis.” THCV vs. Delta-8 THC Like THCV, delta-8 THC is often considered to be less psychoactive than delta-9 THC. If delta 8 can be considered, though, 75% as potent as delta-9, THCV would come in closer to 25% the potency of conventional THC. Also, delta-8 appears to lack the considerable beneficial properties noted with THCV. While THCV has considerable potential in the field of medical research, delta-8 is generally viewed as simply a less-potent version of delta-9 THC. Does THCV Show Up on Drug Tests? Yes, it appears that THCV can cause a false positive for delta-9 THC since drug tests can’t distinguish between the metabolites of the two cannabinoids. If drug testing is a concern for you, it is best to avoid any form of THC, including THCV. Where to Buy THCV You have a few options when it comes to finding the best THCV shop in your area. In fact, the best local THCV store might even be online: Online The online THCV industry is considerably more competitive than anything you’ll find in a local market. As a result, the THCV products you can buy online are higher-quality while being offered at a lower price. Online THCV products are also accompanied by a greater abundance of product information, making it easier to make a decision you’ll stand behind. Vape/Smoke Shops Some local vape and smoke shops might carry THCV products. Other types of THC products are more popular in these shops, however, since THCV doesn’t get you particularly high. Also, the quality of the THCV found inside these seedy establishments should certainly be questioned. Gas Stations Various gas stations and other types of convenience stores have recently started carrying a limited array of THCV products. These products are almost undoubtedly even lower-quality than those sold in vape shops. At least vape shop owners usually know something about cannabis — gas station owners don’t know and don’t care. Dispensaries In some states, you might be lucky enough to have access to legal cannabis dispensaries. These locations mainly traffic in conventional THC, however. Any THCV products present will be few and far between. Information on these products is sure to be even sparser. Summary: It’s Easy to Buy Great THCV Online The hemp cannabinoid revolution originally emerged online, and the internet remains the best place to buy any cannabinoid aside from delta-9 THC. Whether you’re seeking out THCV to control body weight or make your mind fly lighter, an online supplier will be able to cater to your needs best. Always remember, though, that THCV is an intoxicating cannabinoid, making it very different from CBD gummies, CBG, and other hemp cannabinoids with absolutely zero intoxicating effects. Tread with caution, but fully enjoy the unique effects of THCV.

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August 3, 2024

What is CBG Oil? CBG Benefits, Effects, Dosage, & More

Cannabigerol (CBG) isn’t among the most well-known cannabinoids. Odds are you’re reading this because of its recent mainstream attention. Still, CBG is one of the unique compounds in a cannabis plant. Despite its very low concentrations, all major and minor cannabinoids wouldn’t exist without CBG. But as hemp-derived CBG oils become mainstream, the CBG vs. […]

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August 3, 2024

What is CBC and What Are its Benefits?

Cannabichromene (CBC), a cannabinoid found in hemp, isn’t a term most of us know. With CBD becoming the focus of consumers and researchers alike, over 100 other cannabinoids are nearly unnoticed. Make no mistake, though, CBD doesn’t stand alone. Your broad-spectrum or full-spectrum CBD extract wouldn’t be the same without other similar molecules helping fuel […]

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What is CBN and What are its Benefits?