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How CBD Works In The Human Body & The Endocannabinoid System

How CBD Works In The Human Body & The Endocannabinoid System

Aug 03, 2024

Infographic on how CBD works in the human body by interacting with numerous receptors including our Endocannabinoid System

Imagine a drug that has been used medicinally for over 8,000 years.

Medicine of choice in the early 1900s used to help with sleeping, pain, inflammation, and seizures.

Today, that drug is recognized by researchers for its ability to control seizures, suppress cancer growth in cell cultures, slow the progression of Alzheimer’s disease, and provide protection to the brain after a stroke.

A drug like this could be considered a medical miracle, right? It may come as no surprise that this “miracle drug” is in fact cannabis.

For decades, marijuana research has to lead the way for new initiatives in the areas of human biology, health, and diseases, and in the 1990s something wonderful happened. The Endocannabinoid System was discovered and with it the realization that it is a crucial molecular system that helps the human body function.

However, it isn’t something that happened overnight.

Cannabidiol, the non-psychoactive cannabinoid in cannabis, was discovered by researchers in 1894, and it was the first plant-derived cannabinoid discovered.
In 1930 researchers were able to discover the structure of cannabidiol.
In 1940 Cannabidiol (CBD) was discovered.
In 1943 the structure of CBD was discovered.
Science was changed in 1964 when THC (the psychoactive component of cannabis) was discovered and isolated.
1988 led to the discovery of cannabinoid receptors in an animal’s brain.
1990 gave us the first cloned cannabinoid receptor.

Research on How CBD Works Led to the Discovery of the Endocannabinoid System

In the 1990’s researchers finally discovered two of the body’s major endocannabinoids, which lead to the discovery of the endocannabinoid system. This discovery has opened the door to understanding how the endocannabinoid system regulates and affects every major part of the body.

What is the Endocannabinoid System?

According to Project CBD, a California-based nonprofit dedicated to promoting and publicizing research in CBD, the endocannabinoid system is a “biochemical communication system in the human body…which plays a crucial role in regulating our physiology, mood, and everyday experience.” This intricate system is comprised of cannabinoid receptors that react to the psychoactive ingredient in marijuana. In other words–we wouldn’t get high or enjoy the medical benefits of marijuana without our endocannabinoid system.

The endocannabinoid system doesn’t just get us high though.

Researchers have determined that the Endocannabinoid System works to regulate processes like:

Sleep
Appetite
Digestion
Mood
Motor control
Immune function
Reproduction and fertility
Pleasure and reward
Memory
Temperature regulation
Pain

However, the endocannabinoid system can only regulate these areas when working properly. When this system fails, we see an increase in disease and disorders, like migraines, fibromyalgia, and IBS. Thanks to advances in medical science, we’ve discovered that when the body fails to produce enough of its own endocannabinoids, we may be able to supplement with plant cannabinoids.

What’s the Endocannabinoid System made Of?

Consider it like this, the endocannabinoid receptors are locks, and the cannabinoids (like CBD and THC) are keys. Only certain keys will fit certain locks. The largest endocannabinoid receptors are known as CB1 and CB2, and they affect totally different parts of the body. CB1 is found in the central nervous system, while CB2 is found in the immune system. Though they are both parts of the endocannabinoid system, these receptors respond to different signals and express themselves in completely different ways.

CB1 is found on nerve cells in the brain and the spinal cord. Though, they can also be found in smaller amounts on the spleen, white blood cells, endocrine glands, and as part of the reproductive, and digestive tracts. Patients suffering from pain, nausea, and depression respond better to medications that affect these receptors, namely ones that include some level of THC.

CB2 is found on white blood cells, tonsils, the spleen, and in immune cells. Those with Crohn’s disease or irritable bowel syndrome experience more relief from medications that stimulate CB2, in some cases putting patients in full remission.

Unfortunately, every person is different. This means that every person has a different number of receptors in their body, and some can be overexpressed or under-expressed. These same receptors can also respond to a variety of cannabinoids. This complicates the development of therapeutic grade pharmaceuticals for researchers because everyone is going to respond to the medications differently.

How CBD Works in the Human Body

Cannabidiol (CBD) is a non-intoxicating psychoactive cannabinoid that acts as a pleiotropic drug in that it produces many effects through multiple molecular pathways. Pleiotropy refers to the expression of multiple traits by a single gene.

CBD doesn’t directly interact with our two cannabinoid receptors, CB1 and CB2, that many cannabinoids, such as THC or CBG, interact with. Instead, CBD interacts with our endocannabinoids, Endo meaning endogenous or internal and these receptors are considered “endogenous cannabinoids” because cannabinoids interact with them.

The question many people always ask is “how does CBD work in the human body?” We all know it posses many magnificent traits ranging from relieving anxiety to pain and even having anti-cancer properties.

In this section, we’ll go over all the main receptors that CBD interacts with to produce the different medicinal properties we all have seen it do and even some stuff you didn’t know it does such as promoting bone growth.

Anandamide

Anandamide is a molecule within our body named after the Sanskrit word Ananda which means ‘bliss’ or ‘divine happiness.’

It was discovered in 1992 by scientists researching the effects of THC on the brain in the research laboratory of Raphael Mechoulam. Mechoulam is a pioneer in the research of cannabis plant families, including hemp, where you find high concentrations of CBD.

Anandamide functions as a neurotransmitter because it sends messages between nerve cells throughout the nervous system. It mostly affects the brain’s areas that influence pleasure, happiness, cognitive, sensory, and motor functions.

Unlike other receptors, Anandamide is produced on demand rather than sitting in large pools waiting to be released. When CBD is consumed, it increases anandamide production that interacts with receptors in the brain, increasing dopamine levels linked to pleasure and happiness.

Anandamide plays a role in mood regulation, boosting dopamine levels, which increase happiness and joy, reducing pain, managing stress, and regulating sleep, among many other bodily functions.

Ways to increase Anandamide production:

Exercise
Chocolates
CBD
Black Truffles
Fruits and vegetables
Acupuncture

2-arachidonoylglycerol (2-AG)

2-AG, short for 2-arachidonoylglycerol, is the second most widely studied endocannabinoid after anandamide. They also possess many similar properties.

There was an interesting study conducted on 2-AG that was published in The Journal of Sexual Medicine in 2017 by Dr. Sarah Biedermann, MD. In this study, they measured the blood serum levels of anandamide, 2-AG, and cortisol after self-stimulation in both men and women. They found that 2-AG increased during orgasm. However, all other chemicals measured including the “bliss” molecule anandamide, did not change.

2-AG and anandamide are similar in that they are released from the postsynaptic neuron that is receiving the neurotransmitter back across the synapse to interact with the presynaptic neuron sending it.

Sending messages back to the presynaptic neuron that is sending messages allows for many physiological functions to occur. Such as simply telling the presynaptic neuron to stop firing to inducing neuroplastic changes that neural junction.

Something else that is interesting is that 2-AG and anandamide both attach to the CB1 receptor but anandamide, however, anandamide doesn’t attach to the CB2 receptor while 2-AG is a full CB2 agonist, meaning that it’s capable of producing a maximum response.

If you recall from reading about the Endocannabinoid System, CB1 receptors are found mainly in the Peripheral Nervous System (PNS), which consists of the brain and spinal cord. In comparison, the CB2 receptors are found in our Central Nervous System (CNS), which consists of our immune system and inflammation response.

TRPV1

TRPV1, is one of the dozen TRP (pronounced “trip”) receptor subfamilies that mediate a wide range of therapeutic benefits.

It’s also called the “capsaicin receptor” since it’s the primary receptor that capsaicin, an anti-inflammatory compound found in chili peppers, binds to when it enters the body.

TRPV1, also called vanilloid receptor 1, helps control our body temperature and plays a role in how we feel pain. Several methods can activate this receptor:

Temperatures above 109 degrees Fahrenheit
Capsaicin, a molecule responsible for the spicy sensation of chili peppers
Acidic conditions in the body
Anandamide
Cannabidiol (CBD)

The primary function of TRPV1 is to cause searing pain, but prolonged TRPV1 activation reduces pain. It does so by “desensitization” of the receptors, which is achieved by prolonged exposure to activating agents.

CBD as an Allosteric Modulator

CBD has shown to have a unique trait of reducing the intoxicating effects caused by THC. It’s capable of doing this because CBD is an allosteric receptor modulator. This means that it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor. CBD can either be a negative allosteric receptor modulator or positive, which we’ll cover.

CBD is known to act as a negative allosteric receptor modulator to the cannabinoid receptor CB1 found in our Central Nervous System, which is mainly in our brain and spinal cord. The same cannabinoid receptor that THC attaches to produce its intoxicating effects when consumed.

While CBD doesn’t attach directly to the CB1 receptor, studies show that it acts in a negative allosteric method where it changes the shape of the CB1 receptor in a way that weakens CB1’s ability to bind with THC. This explains CBD’s ability to inhibit the intoxicating effects caused by THC. People don’t feel as “high” when consuming CBD-rich cannabis or consuming a THC product along with CBD.

CBD and the GPR55 Receptor

CBD is a GPR55 antagonist, meaning it achieves its effects by blocking GPR55 signaling. This receptor is crucial, as it’s responsible for a variety of functions, which we’ll cover in a second.

According to a 2017 review in the Journal of Molecular Endocrinology, the GPR55 is a new type of endocannabinoid receptor. First discovered in 1999, it exists in both the central and peripheral areas of the body. But it wasn’t until 2007 that we fully understood its connection with the ECS.

A 2016 publication in Current Medical Chemistry explains the many roles of GPR55 receptors, including:

Inflammation
Bone health
Cancer
Diabetes
Neuropathic pain

Coincidentally, plenty of preliminary and anecdotal evidence support’s CBD’s therapeutic or preventative benefits in the above areas.

CBD and the PPARS Receptor

The PPARs are another critical multi-role receptor that interacts with CBD. Unlike GPR55, however, CBD is an agonist, not an antagonist. In other words, it triggers – rather than suppresses – the PPARS receptors.

A 2011 review in the Journal of Advanced Pharmaceutical Technology and Research explored the potential benefits of PPARs agonists in areas like:

Diabetes
Glucose metabolism
Energy balance
Cancer
Inflammation
Neurodegenerative disorders
Pain
Obesity

The study found promising evidence that PPARs agonists (such as CBD) may help improve, control, or prevent a variety of symptoms and conditions. Most notably such cannabinoids show promise for cancer and Alzheimer’s patients.

PPAR activation showing the different ways it affects our body which CBD activates PPAR — This image is recreated from BeyondTHC’s image on PPAR activation in their “How Does CBD Regulate Gene Expression” research paper.

CBD as a Reuptake Inhibitor

CBD’s role as a reuptake inhibitor has huge implications for its potential medicinal properties. Matt Elmes, the director of new product development at Cannacraft gave his expert insight during a 2019 interview.

According to Elmes, cannabinoids like THC and CBD can’t just walk into a cell’s nucleus. They – like endocannabinoids – need to be transported on FABPs (fatty acid-binding proteins).

To put it another way, imagine cannabinoids sneaking into cells like a microscopic Trojan Horse (FABPs being the horse). Once inside, CBD goes to work distributing its effects to places like the nearby PPARS receptors we mentioned earlier.

But there’s a catch. As Elmes explains: “THC and CBD can compete for anandamide uptake.” In other words, CBD and other cannabinoid “passengers” don’t get along.

With CBD on the FABPs, there’s less room for anandamide. Consequently, a large portion of the endocannabinoid gets left behind.

But is this a bad thing? According to Elmes, it’s quite the opposite. Less anandamide in the cell means more stays behind. Elmes explains:

So, if we block that transport step, there’s going to be less anandamide broken down, and hence more anandamide in your body that’s able to signal and hit cannabinoid receptors.

Ultimately, the process improves endocannabinoid receptor signaling. Suddenly, the ECS starts working extra hard to more successfully maintain homeostasis.

Conclusion

The endocannabinoid system is a complex network of receptors that signal the body to maintain a state of functional balance called “homeostasis.”. Our ECS allows us to enjoy the benefits of endocannabinoids and phytocannabinoids (like CBD) for therapeutic or recreational purposes.

Although many cannabinoids directly bind to the CB1 or CB2 receptors, CBD does neither. Instead, it affects other receptors such as GPR55 and PPARs while altering the endocannabinoid receptors.

These interactions and alterations change the way we absorb certain cannabinoids or prevent their effects altogether. Meanwhile, CBD’s effects on non-ECS receptors help provide a range of potential therapeutic benefits.

Despite an information gap, growing research improves our understanding of CBD and often supports many medical claims. It’s pretty likely we’ll see more thorough studies soon.

December 16, 2024

Are Hemp Gummies the Same as CBD Gummies?

All CBD gummies are hemp gummies, but not all hemp gummies are CBD gummies. This basic logical statement could take an entire guide to fully understand, but let’s start by putting it as simply as possible: CBD comes from Cannabis sativa As long as CBD gummies contain less than 0.3% THC, they’re considered “hemp” Hemp gummies can contain cannabinoids other than CBD, though CBG and CBN gummies are common alternatives So, while all CBD gummies must also be hemp gummies to be sold online… Some hemp gummies might contain cannabinoids other than CBD Other hemp gummies might not contain any hemp cannabinoids at all. Hemp seed oil gummies, for instance, are entirely cannabinoid-free. Now, let’s dive into the details: What are hemp gummies, what are CBD gummies, and what’s the difference? What Are Hemp Gummies? Hemp gummies are gummies that contain some sort of extract from the hemp plant — nothing more specific than that. “Hemp oil” can even refer to hemp seed gummies, which only offer nutritional properties. Definition and Ingredients “Hemp” is another word for Cannabis sativa, an ancient plant that has been a companion of humanity since the dawn of history. The hemp plant produces hemp seeds, which can be pollinated to grow new hemp plants. Without pollination, however, hemp seeds remain the fertile nuggets of nutrition from which a new plant would have sprouted. Even human beings can benefit from this nutritional content, which includes omega fatty acids and essential minerals. What hemp seeds don’t contain is cannabinoids, so they won’t cause any of the famous effects of these cannabis-only compounds. Aside from that, hemp seed gummies can contain many of the same ingredients as CBD gummies, such as tapioca starch and cane sugar. Benefits of Hemp Gummies Hemp seed oil gummies are useful for their nutritional benefits. They aren’t useful for any of the reasons CBD gummies are beneficial, but they can fill gaps in your diet or even provide your body with an excess of the nutrients it needs, potentially improving your health. Keep in mind that “hemp gummies” doesn’t only refer to hemp seed oil gummies. Gummies with CBD or any other cannabinoid are also “hemp gummies,” technically, so you could say the benefits of hemp gummies encompass their benefits, too. Legal Status Hemp seed oil gummies and hemp-derived CBD products are generally viewed the same under the law as long as they contain less than 0.3% THC, the intoxicating substance still banned by the federal government and defined as “marijuana.” So, while hemp seed oil gummies don’t contain any cannabinoids at all, CBD gummies enjoy the exact same legal status so long as their THC content remains below the federally mandated threshold. What Are CBD Gummies? CBD gummies are hemp gummies, but they’re a special type of hemp gummies. They contain cannabidiol, a unique cannabinoid that doesn’t get you high. Definition and Ingredients CBD gummies are defined by their high concentration of cannabidiol (CBD), the second-most abundant cannabinoid in the hemp plant. While THC might be more common in hemp and cannabis, CBD has a major advantage — it doesn’t get you high. Unlike hemp seed oil gummies, CBD gummies can contain a small amount of THC — not enough to cause issues from a federal legality standpoint, but potentially enough to make you fail a drug test. The tradeoff is CBD’s incredible benefits: Users swear that CBD helps with their pain, sleep, and anxiety. Benefits of CBD Gummies CBD gummies are an easy and convenient way to take CBD anytime, anywhere. It’s no trouble to take CBD gummies since they’re chewable and delicious, and a single gummy can contain as much as 25mg CBD — certainly an effective dose. The overall benefits of CBD remain under investigation, but the cannabinoid has been investigated for its ability to: Reduce pain Facilitate sleep Manage anxiety Help with epilepsy Heal the nervous system & much more Types of CBD in Gummies Just knowing that a gummy contains CBD doesn’t really tell you that much. Full-spectrum CBD gummies are a lot different from the broad-spectrum equivalent, for instance, and both are better than gummies with CBD isolate. Full Spectrum CBD Full-spectrum CBD contains the entire spectrum of cannabinoids in cannabis — even THC. Federal law limits THC concentrations to 0.3% THC or less, however: not enough to get you high, but enough to trigger the entourage effect to the fullest. Broad Spectrum CBD Broad-spectrum CBD oil is the same as full-spectrum hemp extract but without any THC at all. In broad-spectrum CBD gummies, the THC has been removed, but the other beneficial components of cannabis remain intact. Users prefer this option if they are commonly drug tested or are sensitive to THC. CBD Isolate Mostly outmoded, isolate CBD is a THC-free legacy ingredient that consists only of the CBD molecule. With the advent of broad-spectrum CBD, isolate became obsolete, but some companies may still use it in gummies to cut on costs. Legal Status CBD gummies are considered the same as any other hemp product if they contain less than 0.3% THC. In other words, they’re legal in all 50 states and can be shipped and carried over state lines. Some individual jurisdictions may have laws against CBD, but they only pertain to CBD sales and use within those jurisdictions. Hemp Gummies vs. CBD Gummies: Key Differences Let’s dive a bit deeper into the similarities and differences between hemp gummies and gummies that specifically contain CBD: Source of Ingredients CBD gummies contain CBD extract, which comes from the same botanical species that people sometimes call “marijuana plants.” These cannabis plants contain low THC, however, and they’re — in fact — no different from the plants from which manufacturers derive hemp seeds. CBD gummies and hemp seed oil gummies both contain ingredients derived from hemp, just from different parts of the plant. Cannabinoid Content Hemp seed oil gummies should not contain any cannabinoids whatsoever. CBD gummies, on the other hand, can contain high concentrations of cannabinoids — just less than 0.3% THC. Put another way, hemp seed oil gummies are cannabinoid-free, but if you could say the same about CBD gummies, they’d lose their purpose. Primary Uses People mainly use hemp seed oil gummies as nutritional supplements since they’re great sources of essential fatty acids and other nutrients. CBD gummies, on the other hand, are relied upon primarily for their potential health benefits. Hemp seed oil might have certain therapeutic benefits too, but they’re certainly eclipsed by the healing power of CBD. Taste and Texture There shouldn’t be a massive difference between hemp and CBD gummies in terms of taste or texture. Gummies have roughly the same texture regardless of their ingredients, and most hemp gummies of any kind mask the taste of the cannabis plant with sweeteners and flavoring. Connoisseurs, though, may find hemp seed oil gummies to taste more “nutty” while CBD gummies are more “herbal.” Price Comparison CBD gummies might be somewhat more expensive than gummies containing just hemp seed extract. It all depends on the quality of the ingredients and the ethics of the company, though — it’s just as easy to charge too much for too little as it is to offer more value than customers commonly expect. Labeling and Misconceptions Sometimes, the very labeling attached to hemp or CBD gummies can make it easier to confuse the two. To make it simple, keep an eye out for two keywords: “CBD” and “hemp seed.” With CBD gummies, the term “hemp seed” should not be printed anywhere on the packaging or accompanying labeling material. Conversely, hemp seed oil gummies do not contain CBD, so the acronym should not be present on their labeling. How to Choose Between Hemp Gummies and CBD Gummies In the end, making the choice between hemp seed gummies and CBD gummies is easy. Let’s slim the question down: Determine Your Goals Are you mainly looking to fill nutritional gaps, or are you seeking relief from daily aches and pains? Hemp seed oil gummies are good for the former, and CBD gummies for the latter. Check the Label Don’t make a mistake: Check the labeling, whether online and person, attached to any CBD or hemp gummy product you’re considering to make sure you end up with the right product. Consider Budget and Availability Hemp seed oil gummies can sometimes be less expensive than CBD gummies, but not always. Both CBD and hemp seed gummies are widely available all throughout the United States due to the modern wonders of eCommerce. Are Hemp Gummies or CBD Gummies Right for You? Summing it up just once more, hemp seed gummies are for those pursuing nutritional goals, and CBD gummies are for those seeking help with chronic health concerns. This simple assessment doesn’t cover every single gummy user — certainly not. But, if you’re still on the fence, just consider this final question: Better nutrition, or a natural health remedy? Which is it you’re seeking most? FAQs About Hemp Gummies vs. CBD Gummies Where can I buy CBD gummies? You can buy CBD gummies, CBD oils, CBD softgels, CBN oils, CBD for dogs, CBG oils, and all kinds of other CBD products easily and with an informed perspective when you shop on the internet. With online CBD shopping being so simple and rewarding, there’s no need to wonder where to buy CBD gummies any longer. Trust Colorado Botanicals as the internet’s premier source of organic CBD products since 2017. Do hemp gummies contain CBD? Some hemp gummies contain CBD, but not all. Check the packaging specifically for the acronym CBD: Just because a product is labeled “hemp gummies” doesn’t necessarily mean it contains CBD. Can hemp gummies help with anxiety or sleep? Yes, in addition to using CBD gummies for pain, people often use them for reducing anxiety and improving sleep as well. Just remember to choose an appropriate dosage of CBD gummies to take before you dive into everything this non-intoxicating cannabinoid has to offer. Are hemp gummies legal? Yes, hemp gummies are legal in the same way that CBD oil is legal: As long as they contain less than 0.3% THC, they are considered industrial hemp and can be sold online. How old do you have to be to buy CBD gummies online? There is no federal age limit for buying CBD online, so it’s up to CBD companies to impose age limits. Most CBD companies ask that their customers be at least 18-21 years old to make purchases. This policy is not a legal requirement, but it does conform with many state laws on CBD purchases. Can I travel with CBD? Yes, it is legal to travel with CBD over state lines if it contains less than 0.3% THC. In regards to airline travel, the TSA has stated that it no longer searches for CBD or other hemp and cannabis products. So, you should have no trouble traveling with CBD, but always check the laws of the specific jurisdiction you are traveling to if you want to ensure a hassle-free trip. How do I know if my gummies contain CBD? You’ll be able to tell if gummies contain CBD by looking for the acronym “CBD” anywhere on the labeling. Hemp gummies that don’t contain CBD will be labeled as “hemp,” but “CBD” will be absent from the packaging. Are there any side effects of hemp or CBD gummies? In almost every case, CBD will make you feel lightly relaxed with no side effects. The same goes for hemp seed oil gummies, which are very unlikely to have any side effects at all. Gummies with CBD, though, can cause mild side effects like: Dry mouth Sleepiness Digestive discomfort In some cases, a rare cannabis allergy can occur. CBD may also interact with certain prescription medications. Consult with your doctor if you’re currently using any medications before trying CBD gummies. Can I take hemp and CBD gummies together? Yes, there’s no reason you shouldn’t take hemp seed oil gummies and CBD gummies at the same time. Doing so might even be considered a truly “whole-plant” cannabis experience — you’re getting the benefits of both the seeds and flowers of the plant simultaneously. Which are better: hemp gummies or CBD gummies? When considering hemp gummies vs. CBD gummies, you have to keep your needs in mind first and foremost. Gummies with CBD provide completely different effects from hemp gummies that don’t, so start by educating yourself on what sets these two categories of hemp products apart. From there, decide which is better for you based on the specific effect profile offered by each option. Conclusion: Are Hemp Gummies the Same as CBD Gummies? It’s easy to confuse hemp gummies with CBD gummies. To set the record straight one final time: All CBD gummies are hemp gummies because CBD is considered a hemp extract Not all hemp gummies are CBD gummies, however, because some hemp gummies contain other cannabinoids or just hemp seed oil Hemp plant seeds can be useful for nutritional purposes, but that’s not what we’re looking for in CBD. Gummies with CBD are designed to deliver this cannabinoid quickly and deliciously — no hassle and no mess.

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December 8, 2024

Do CBD Gummies Get You High?

CBD gummies shouldn’t get you high. They aren’t designed to — while CBD is highly relaxing, it lacks the intoxicating properties that have made THC both famous and infamous as a recreational substance. Getting high isn’t popular with everyone, and CBD gummies give you an alternative that still delivers the benefits of cannabis. Learn more about CBD gummies in this guide to make sure you know why they won’t get you high. What Are CBD Gummies? CBD gummies are convenient and tasty edibles that deliver all the benefits of CBD and cannabis but without any mess or high. Similar to gummy vitamins you may have taken, CBD gummies are easy to pack with you and snack on whenever you feel the urge. Gummies that contain CBD can include a wide variety of additional ingredients. As people have learned more about healthy ingredients, the CBD gummy industry has gradually gravitated toward simple ingredients like tapioca starch and cane sugar, which have the potential to be organic. Do CBD Gummies Contain THC? While some CBD gummies contain a small amount of THC, another shift the CBD gummy industry has taken recently is toward broad-spectrum CBD extract. Full-spectrum CBD gummies can contain up to 0.3% THC, but broad-spectrum CBD gummies remove the THC while leaving all the other beneficial components of cannabis plants intact. Broad-spectrum has a clear advantage over CBD isolate, which only contains CBD. Unlike full-spectrum CBD products, though, broad-spectrum CBD gummies don’t pose any chance at all of getting you high, even if you’re extremely sensitive to THC. What Is THC? Delta-9 tetrahydrocannabinol is the cannabinoid most commonly referred to as “THC,” though the acronym can refer to any cannabinoid in the THC family. All forms of THC are alike in that they cause at least some degree of intoxication, and delta 9 THC causes greater activation of your brain’s high-inducing CB1 receptors than any other common natural cannabinoid. Banned outright in many countries and existing within a precarious legal state in the USA, THC is a contentious subject worldwide. CBD brands have striven extensively to associate their cannabinoid with hemp to avoid THC stigma — even though, scientifically speaking, hemp and cannabis are the same plant. THC vs. CBD One of the other cannabinoids commonly found in Cannabis sativa is CBD, often used to make CBD oil. Since the early 2010s, the world has looked on, spellbound, as CBD has seemingly performed miracle after miracle, becoming the new millennium’s preferred panacea. Studies on CBD have confirmed rather than denied its impressive traits — though scientists and regulators still urge caution when making specific medical claims. Whatever the exact facts may be on CBD, the obvious truth is that it has helped countless people. And, all without getting any of them unwantedly high. Do CBD Gummies Get You High? No, CBD gummies should not get you high as long as they comply with federal law and contain less than 0.3% THC. Even full-spectrum CBD gummies, which contain some CBD, can’t include any more than 0.3% of the substance, which isn’t enough to cause intoxication for the vast majority of individuals. The entourage effect, offered by both broad-spectrum and full-spectrum CBD gummies, can certainly enhance the effects of CBD. This enhanced psychoactivity could hardly be called a high, however. It just makes the relaxing effects of CBD more relaxing. If you’re unusually sensitive to THC, the less-than-0.3% of the substance present in full-spectrum CBD could cause a reaction. For children, individuals with cannabis allergies, or those recovering from THC dependency, therefore, THC-free broad-spectrum CBD gummies are the clear choice. Factors that Influence the Effects of CBD Gummies In addition to the dosage you consume, your individual tolerance to CBD can considerably impact how CBD gummies affect you. Also, while the differences are subtle, full-spectrum and broad-spectrum CBD extracts can have noticeably different effects for some users. Then, there’s also the overall quality of the CBD gummies to consider. CBD gummies containing high-quality CBD extract and natural or organic accompanying ingredients will likely have a stronger and more enjoyable effect compared to low-quality gummies. That’s part of why you should always check the ingredients when you buy CBD gummies online. Benefits of CBD Gummies Without the High CBD gummies with zero-THC extracts like broad-spectrum CBD come with a lot more benefits than just not getting you high. They make it possible for you to experience the benefits of CBD more fully, for instance, which people rely on for getting to sleep, relaxing, and reducing stress. When you choose zero-THC CBD gummies, there’s no chance of your daily activities being impaired. While CBD might exacerbate any latent sleepiness that’s already there, you deserve a power-nap, anyway. Here are some other ways you might benefit from choosing zero-THC CBD gummies: No drug test worries Not a problem with employers Better effects, some say No concerns over your CBD being confused with “medical marijuana” Complies with the letter of many anti-cannabis state laws Broad-spectrum CBD is more refined and often higher quality How to Choose the Right CBD Gummies There are quite a few different CBD gummies to choose from. Knowing how to pick the right option, therefore, is necessary if you want to end up with the exact results you’re envisioning. Here are some of the most important factors to consider as you make your choice: Always Check for Lab Reports Just like returning your cart when you’re done shopping at the grocery store, having third-party lab reports commissioned for each batch of CBD products isn’t a legal requirement. How seriously CBD companies take independent lab reporting, however, tells you just as much about them as your shopping cart choices say about you. Some companies skimp on their lab reports by not testing every batch or only testing for certain contaminants. A full certificate of analysis or “COA” for a CBD product includes: A date A batch number Cannabinoid concentrations Terpene concentrations Mycotoxin screen Bacterial screen Pesticide screen Heavy metal screen Information about the issuing lab Lab contact information If a CBD lab report lacks any of these points, consider choosing a different source for your CBD gummies. Choose Reputable Brands These days, you can learn everything you need to know about CBD brands by spending just a few minutes searching the internet. Trusted brands like Colorado Botanicals have hundreds of verified reviews on independent sites like TrustPilot, displaying a level of transparency and accountability that’s rare to find in the industry. If you’re not sure whether or not to trust a CBD company, reach out. How quickly and how well they respond to your inquiry can be the deciding factor in your search. Identify the Type of CBD That Suits Your Needs For each individual out there in search of CBD, there’s a gummy that suits their exact needs. Considerations to make include how many gummies you should eat in a serving compared to the dosage of the particular CBD gummies you’re considering. 25mg CBD gummies pack a lot more CBD per gummy than the 10mg equivalent, for instance. Also, CBD brands vary considerably in terms of their reputation and the quality of the products they offer. Other considerations include flavor preference and tolerance to additional ingredients that may be present in the CBD gummy formula. Do CBD Gummies Have Side Effects? Yes, CBD gummies can have side effects, usually only amounting to sleepiness, slight digestive discomfort, or dry mouth. In rare cases of cannabis allergy or when you are taking other medications at the same time, however, more serious side effects can occur. Also, full-spectrum CBD gummies can cause a very slight THC high in individuals who are sensitive to this substance, leading many to choose broad-spectrum gummies instead, which don’t have this side effect. If you’re concerned that CBD gummies are causing unwanted effects, stop using them immediately, and consult with a doctor. Frequently Asked Questions Learn more about why CBD gummies shouldn’t get you high below: Do CBD gummies have THC in them? CBD gummies can sometimes contain THC, especially in the case of marijuana-derived CBD such as is available at adult-use or medical cannabis dispensaries. The types of CBD gummies you can buy online, however, contain less than 0.3% THC by federal law. That’s not enough for most people to notice the effects of THC even the slightest bit. Can full-spectrum CBD gummies get you high? There’s a low chance that full-spectrum CBD gummies might make you feel the faintest bit of a high due to their up-to-0.3% THC concentration. On its own, CBD does not have any considerable psychoactive properties. Even 0.3%, though, could be enough to trigger a mild THC high in some individuals. Can you drive after taking CBD gummies? Whether it’s CBD or prescription medications, it’s never a good idea to get behind the wheel if you’re even the slightest bit impaired. Low doses of CBD, however, are very unlikely to impair you in any way. 10mg CBD gummies and other low-dose options are great choices if you want to enjoy CBD without becoming too sleepy or otherwise impaired to drive. How do I know if my CBD gummies are THC-Free? Most CBD gummies that do not contain THC feature clear labeling advertising this benefit. If you aren’t sure whether or not CBD gummies contain any THC, check for the term “full-spectrum” anywhere in the labeling. Full-spectrum CBD gummies contain up to 0.3% THC, but other types of CBD gummies do not. If the information you’re looking for is still hard to find, check the lab report for the CBD gummies in question. If the listed THC concentration is anything but “0.00%,” then the gummies you’re considering aren’t THC-free. Can kids take CBD gummies? It’s up to parents to decide whether their kids can have CBD gummies. Parents who want to avoid giving their kids THC should choose broad-spectrum CBD gummies. These types of CBD gummies have no chance of causing an unwanted high in children. Investigate the other ingredients present in CBD gummies for kids as well to make sure they’re safe and healthy. Summary: CBD Gummies & Intoxication CBD gummies are not designed to cause intoxication. Even full-spectrum gummies, which contain up to 0.3% THC, usually won’t cause any amount of intoxication, even in sensitive individuals. For some people, though, even a fraction of a percent of THC is enough to cause something at least similar to a high. Especially when giving CBD gummies to children, it’s understandable why you might want to avoid THC altogether. That’s why it’s fortunate that we now have access to high-quality and reliable broad-spectrum CBD gummies. Broad-spectrum extract offers the entourage effect just like full-spectrum CBD, but without any THC whatsoever. If you’re worried about CBD gummies making you fail a drug test or getting you or your kids high, choose broad-spectrum CBD, and enjoy this cannabinoid’s incredible effects entirely worry-free.

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December 5, 2024

CBD for Kids: Is It Safe and Legal? Everything to Know

Some of the first stories we heard about CBD involved children. The nation was enraptured in the early 2010s when parents flocked to Colorado and saw their terminally epileptic children experience incredible levels of recovery. Those children, though, had serious illnesses that weren’t receptive to any other treatment. Is it equally appropriate to give CBD to kids for sleep, hyperactivity, or anxiety? Learn the facts about CBD and kids in this guide, from whether it’s legal for kids to take CBD to the best kinds of CBD products for kids to take. What is CBD? Cannabidiol (CBD) is a naturally occurring component of the hemp plant. In recent years, breeders have created high-CBD forms of cannabis, resulting in an abundance of this non-psychoactive but highly medicinal cannabinoid. CBD doesn’t get you high. What it does, on the contrary, is interact with systems in the body that control mood, pain, and inflammation. The main basis behind recommending CBD for kids is the cannabinoid’s impressive benefit profile combined with its total lack of intoxicating attributes. Types of CBD It’s possible to extract CBD from the hemp plant and further refine it in a variety of ways. Here are a few of the options that are available when it comes to CBD extract types currently on the market: Full Spectrum The original form of CBD extract, full-spectrum CBD contains up to 0.3% THC, making it unsuitable for children. Even at these low levels, it’s possible that THC might have a deleterious effect on childhood development. Broad Spectrum Broad-spectrum CBD was developed as an alternative to full-spectrum extracts. It retains the full medley of cannabinoids and terpenes that combine with CBD to offer the entourage effect, but THC is entirely eliminated from the equation. That’s why broad-spectrum is generally considered the best CBD for children. CBD Isolate Before broad-spectrum CBD came CBD isolate, which consists solely of the CBD molecule. Any opportunities for entourage effect synergy are lost, diminishing the benefits of taking CBD. For the most part, CBD isolate has been phased out in preference to broad-spectrum CBD. What are the Benefits of CBD for Kids? There’s plenty of evidence that CBD might help kids (and also their parents!) with a variety of different mood-related and medical issues that can crop up over the years. Here’s why scientists believe CBD might help kids with sleep, anxiety, and other common problems: Sleep Scientific inquiries into using CBD for sleep have had mixed results with scientists left pondering why so many anecdotal reports indicate that CBD helps with getting better sleep at night. At least one large, clinical study confirms these findings, linking CBD’s apparent ability to help with sleep with its impact on anxiety. Anxiety Rates of anxiety in kids have skyrocketed post-lockdown, leading parents to seek solutions that won’t further harm their precious children. There’s plenty of reason to believe that CBD should be taken seriously as a treatment for anxiety disorders, with scientific literature dating back to 2015 supporting further research into the subject. ADHD Though it’s a comparatively new subject of inquiry, research is mounting that indicates CBD should be looked at as a potential attention deficit hyperactivity disorder (ADHD) treatment for children. Clinical trials remain lacking, but a series of case studies published in 2022 strongly indicates that CBD treatment might strikingly improve scores on commonly used ADHD tests. Autism The full details of the pathogenesis and even the scope of the condition known as autism spectrum disorder (ASD) continue to be debated in the halls of psychopharmacology. What parents with children who have been diagnosed as autistic have found, though, is that CBD sometimes provides a feeling of calm that is otherwise very hard to come by. Pain We may try to shelter our children, but we’ll all experience pain — whether it’s acute or chronic pain — at some point in life. From scrapes and bruises to chronic conditions, CBD might be able to help with all sorts of pain due to its effects on both the TRP and 5HT neuroreceptor families. Epilepsy It can be easy to forget after so much time has passed, but the CBD movement was originally founded upon the efforts of loving parents to provide CBD hemp treatment to their epileptic children. Studies continue to be published every year regarding the beneficial effects CBD may have against epilepsy in both children and adults. Is CBD Safe for Kids? There isn’t much published research regarding the safety of kids taking CBD. In adults, doses of up to 1,500mg CBD per day have been shown to be well-tolerated, but it’s unclear how the safety parameters of CBD might change (if at all) when children take the cannabinoid. What we do know about childhood development might give any parent pause if they’re considering giving their child CBD for any but the most important reasons. The brains and bodies of children grow best when uninterrupted by any drugs or medical interventions. Even as an extremely mild cannabinoid, there’s no knowing how taking CBD might affect a child’s development — for better or for worse. With all that said, it’s very unlikely for there to be any harmful impact from giving a child a small dose of CBD every now and again. Just consider your choices a bit more deeply if you’re thinking of giving your kid high doses of CBD every day. Is It Legal to Give Your Child CBD? There are no federal laws that would prohibit a parent giving CBD to their child. There is no federal age limit on CBD, after all, and CBD is considered legal from the federal perspective. Certain states and municipalities might disagree, but you have parental rights as an American citizen. Those rights include deciding what is best for your children. If you consider all the facts and decide that giving your child CBD might be a good idea, no governmental authority has the legal right to stop you. What to Look for When Buying CBD for Your Child Practice the same level of discernment when choosing the right CBD product for your kid as you did when you were deciding whether CBD was right for your children in the first place: Buy Broad Spectrum CBD for Kids For adults, using THC can be a responsible choice. For kids, however, ingesting THC is never appropriate in any concentration. That’s why thoughtful parents choose broad-spectrum CBD products, which offer all the same benefits as full-spectrum CBD but without any THC whatsoever. Third-Party Lab Reports Learning how to find and read third-party lab reports is an important skill to gain on your CBD journey. Thorough lab reports can tell you everything you need to know about a particular CBD product, from whether it contains any THC to concentrations of residual solvents and pesticides. Brand Reputation In the modern age of internet transparency, it’s easy to learn all there is to know about a CBD company — even what they don’t want you to know. Third-party sites like Trustpilot can help you get to know a CBD company before you buy their products. Colorado Botanicals has a 5-star average on Trustpilot across more than 270 reviews. As one of the only CBD companies to offer THC-free CBD since launching in 2018, Colorado Botanicals has been featured in Forbes and Observer and offers CBD products that are not only contaminant-free but also organic, non-GMO, and always gluten-free. What Is the Best CBD for Kids? Broad-spectrum is best for kids, and Colorado Botanicals offers the best broad-spectrum CBD you can buy online. As you plot a course toward better health for your child, we’d recommend considering our 300mg Broad Spectrum CBD Oil and our 750mg Broad Spectrum CBD Oil. What Are the Best CBD Gummies for Kids? Especially when choosing gummies for your children, it’s important to steer clear of unnecessary sweeteners and dangerous additives. Free of all artificial flavors and colors and subjecting to the same testing as our other products, Colorado Botanicals Broad Spectrum CBD Gummies are an ideal choice for children. FAQs About CBD and Children What are the benefits of CBD for children? Just like adults, children can benefit from the relaxing and soothing properties of CBD. Many parents report that CBD helps their children with anxiety, sleep, and ADHD. Do I need a prescription for CBD for my child? No, it is not necessary to receive a prescription to buy CBD for your child. This is only required in the case of Epidiolex, a synthesized form of CBD sold as a pharmaceutical drug. Buying CBD on the internet does not require any licensing or authorization whatsoever. Most CBD companies ask that their customers be at least 18 years old, however. Can my child take CBD with other medications? Ask your doctor if CBD will interfere with any medications your child is already taking. Certain medications, including those that come with “grapefruit warnings,” can interfere with CBD. View our full CBD drug interactions list for details. How much CBD should I give my child? There is no official established dose for pediatric CBD. Most parents start with a small dose of 5-10mg CBD and move upward from there if their children need it. What should I do if my child experiences side effects from CBD? If your child shows any signs of side effects after using CBD, stop using any CBD products you have already tried, and contact your doctor. Only try CBD again after you’ve firmly established that no allergies or other dangerous conditions are present. Final Word: Should Kids Take CBD? In the initial flurry of unproven medical claims and baseless cannabis stigma, it was easy to forget both that CBD isn’t “medical cannabis” and that it isn’t officially approved to treat children, either. Rather, CBD exists in a middle ground, leaving it up to parents to decide whether the cannabinoid is right for their kids. Regardless of what the Food and Drug Administration said on the matter, parents felt CBD had the power to combat anxiety, ADHD, and even epilepsy in their children. The thriving CBD industry we have today exists largely due to their efforts. Do your part in carrying the CBD industry forward into the future by selecting only the best broad-spectrum CBD for your kids — and yourself!

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How CBD Works In The Human Body & The Endocannabinoid System

Research on How CBD Works Led to the Discovery of the Endocannabinoid System

What is the Endocannabinoid System?

What’s the Endocannabinoid System made Of?